Answer to Question 1
Selenium is one of the body's antioxidant nutrients, working primarily as a part of proteinsmost notably, the glutathione peroxidase enzymes. Glutathione peroxidase and vitamin E work in tandem. Glutathione peroxidase prevents free-radical formation, thus blocking the chain reaction before it begins; if free radicals do form and a chain reaction starts, vitamin E stops it.
Answer to Question 2
Two rare genetic disorders affect copper status in opposite directions. In Menkes disease, the intestinal cells absorb copper, but cannot release it into circulation, causing a life-threatening deficiency. Treatment involves giving copper intravenously. In Wilson's disease, copper accumulates in the liver and brain, creating a life-threatening toxicity. Wilson's disease can be controlled by reducing copper intake, using chelating agents such as penicillamine, and taking zinc supplements, which interfere with copper absorption.
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