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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
The most destructive flu epidemic of all times in recorded history occurred in 1918, with approximately 20 million deaths worldwide.
All adverse reactions are commonly charted in red ink in the patient's record and usually are noted on the front of the chart. Failure to follow correct documentation procedures may result in malpractice lawsuits.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.