Answer to Question 1
Shock can impair numerous organ systems. The abnormal delivery of oxygen and nutrients to tissues and insufficient removal of wastes result in irreversible injury to cells and tissues. Although each organ system is affected differently, ultimately one or more organs may begin to fail. The failure of one organ may place excessive demands on another, causing the second to fail as well. The progression of SIRS to MODS reflects the inability of the body's defenses and medical treatments to counter the detrimental effects of a sustained and potent inflammatory response. Although the clinical course of MODS differs substantially among patients, the sequence of organ dysfunction often follows a similar pattern: first the lungs fail, then the heart, and finally the liver, kidneys, and GI tract. Other organs or systems may also become involved, and each additional failure reduces the likelihood of survival.
Answer to Question 2
A
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