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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
Women are 50% to 75% more likely than men to experience an adverse drug reaction.
After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
There are more sensory neurons in the tongue than in any other part of the body.