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In 1864, the first barbiturate (barbituric acid) was synthesized.

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More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.

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The shortest mature adult human of whom there is independent evidence was Gul Mohammed in India. In 1990, he was measured in New Delhi and stood 22.5 inches tall.

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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.

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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.

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