|
|
Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
Elderly adults are at greatest risk of stroke and myocardial infarction and have the most to gain from prophylaxis. Patients ages 60 to 80 years with blood pressures above 160/90 mm Hg should benefit from antihypertensive treatment.
In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.
By definition, when a medication is administered intravenously, its bioavailability is 100%.
The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
![Lake position in the landscape and proportion of water received as groundwater (data from Webster et](https://biology-forums.com/gallery/47/medium_33_19_02_12_5_42_32_20651521.jpeg)
![Intradermal drug administration: (b) the administration site is prepped Source: Pearson Education/PH](https://biology-forums.com/gallery/47/medium_46687_08_12_14_4_59_34_19527496.jpeg)