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In 1864, the first barbiturate (barbituric acid) was synthesized.
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The first monoclonal antibodies were made exclusively from mouse cells. Some are now fully human, which means they are likely to be safer and may be more effective than older monoclonal antibodies.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Many supplement containers do not even contain what their labels say. There are many documented reports of products containing much less, or more, that what is listed on their labels. They may also contain undisclosed prescription drugs and even contaminants.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.