Question 1
Which of the following contributes to maintaining linkage disequilibrium in a population?
◦ migration of individuals with new SNP haplotypes into the population
◦ mutation
◦ recombination
◦ natural selection
◦ having a very small distance between genes and their syntenic genetic markers
Question 2
Which of the following is true regarding comparison of the physical maps and recombination maps?
◦ There is a linear relationship between recombination frequency and physical distance if the genes are separated by more than 50 cM.
◦ Only with recent genome sequence analysis, which compares physical and recombination maps, has it been possible to determine that recombination hotspots are distributed evenly throughout the
Drosophila genome.
◦ Map distances calculated by recombination frequencies can underestimate the physical distance between two genes.
◦ Two genes with a coldspot between them have larger recombination frequencies than predicted by their physical distances.
◦ Two genes with a hotspot between them have smaller recombination frequencies than predicted by their physical distances.
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