Question 1
Which of the following contributes to maintaining linkage disequilibrium in a population?
◦ migration of individuals with new SNP haplotypes into the population
◦ mutation
◦ recombination
◦ natural selection
◦ having a very small distance between genes and their syntenic genetic markers
Question 2
Which of the following is true regarding comparison of the physical maps and recombination maps?
◦ There is a linear relationship between recombination frequency and physical distance if the genes are separated by more than 50 cM.
◦ Only with recent genome sequence analysis, which compares physical and recombination maps, has it been possible to determine that recombination hotspots are distributed evenly throughout the
Drosophila genome.
◦ Map distances calculated by recombination frequencies can underestimate the physical distance between two genes.
◦ Two genes with a coldspot between them have larger recombination frequencies than predicted by their physical distances.
◦ Two genes with a hotspot between them have smaller recombination frequencies than predicted by their physical distances.
A recombination-based map of one of the chromosomes of Drosophila
Proportions of the genetic and physical maps are similar but not identical
Eqiupment and supplies for physical assessment
Patient Physical Status Classification
Comparison between human chromosome 21 and chimpanzee chromosome 22