The 'two-hit' hypothesis suggests that ________.

[iveyjurea]

Question 1

Sporadic retinoblastoma is often confined to one eye, not both eyes, because homozygous RB1 mutations ________.
◦ are rare
◦ affect only one eye
◦ require one other mutation, a 'second-hit' to cause cancer
◦ are embryonic-lethal
◦ prevent cell division

Question 2

The 'two-hit' hypothesis suggests that ________.
◦ once one allele of a gene is mutated, the other allele must be mutated in order to result in cancer
◦ mutations in one gene promote cancer and mutations to other genes prevent cancer
◦ mutations in two genes in the same cell is usually required for cancer progression
◦ two mutations in the same gene are required for that gene to become oncogenic
◦ both eyes must contain mutations in the RB1 gene in order to develop retinoblastoma

[Heffejeff]

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[iveyjurea]

Great answer, keep it coming

[Sarahjh]

Excellent