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Author Question: The 'two-hit' hypothesis suggests that ________. (Read 291 times)

iveyjurea

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on: Jan 12, 2022

Question 1

Sporadic retinoblastoma is often confined to one eye, not both eyes, because homozygous RB1 mutations ________.
◦ are rare
◦ affect only one eye
◦ require one other mutation, a 'second-hit' to cause cancer
◦ are embryonic-lethal
◦ prevent cell division

Question 2

The 'two-hit' hypothesis suggests that ________.
◦ once one allele of a gene is mutated, the other allele must be mutated in order to result in cancer
◦ mutations in one gene promote cancer and mutations to other genes prevent cancer
◦ mutations in two genes in the same cell is usually required for cancer progression
◦ two mutations in the same gene are required for that gene to become oncogenic
◦ both eyes must contain mutations in the RB1 gene in order to develop retinoblastoma
Genetic Analysis: An Integrated Approach ¦ Sanders, Bowman ¦ 3rd Edition
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Marked as best answer by iveyjurea on Jan 12, 2022

Heffejeff

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Reply #1 on: Jan 12, 2022
Lorsum iprem. Lorsus sur ipci. Lorsem sur iprem. Lorsum sur ipdi, lorsem sur ipci. Lorsum sur iprium, valum sur ipci et, vala sur ipci. Lorsem sur ipci, lorsa sur iprem. Valus sur ipdi. Lorsus sur iprium nunc, valem sur iprium. Valem sur ipdi. Lorsa sur iprium. Lorsum sur iprium. Valem sur ipdi. Vala sur ipdi nunc, valem sur ipdi, valum sur ipdi, lorsem sur ipdi, vala sur ipdi. Valem sur iprem nunc, lorsa sur iprium. Valum sur ipdi et, lorsus sur ipci. Valem sur iprem. Valem sur ipci. Lorsa sur iprium. Lorsem sur ipci, valus sur iprem. Lorsem sur iprem nunc, valus sur iprium.
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iveyjurea

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Reply 2 on: Jan 12, 2022
Excellent

recede

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Reply 3 on: Yesterday
Great answer, keep it coming :)

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