Question 1
What reagents are used to carry out the iodination of benzene?
◦ I
2/FeCl
3◦ I
2/CuCl
2◦ I
2/AlCl
3◦ I
2/CCl
4◦ NaI/Acetone
Question 2
In order, what are the major steps involved in an electrophilic aromatic substitution reaction?
◦ 1) Formation of an electrophile; 2) Reaction of the electrophile with an aromatic ring to form the sigma complex; 3) Deprotonation of the sigma complex to restore aromaticity
◦ 1) Deprotonation of the aromatic ring to increase its reactivity; 2) Addition of the electrophile to form the sigma product; 3) Loss of the leaving group to form the product
◦ 1) Deprotonation of the aromatic ring to form a sigma complex; 2) Reaction of the sigma complex with the electrophile
◦ 1) Polarization of a dihalide, yielding a nucleophile; 2) Reaction of the nucleophile with the aromatic ring to form an electrophile; 3) Loss of the leaving group to restore aromaticity
◦ 1) Reaction of an electrophile with an aromatic ring to form a sigma complex; 2) Deprotonation of the aromatic ring to form the aromatic product
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