Question 1
What reagents are used to carry out the iodination of benzene?
◦ I
2/FeCl
3◦ I
2/CuCl
2◦ I
2/AlCl
3◦ I
2/CCl
4◦ NaI/Acetone
Question 2
In order, what are the major steps involved in an electrophilic aromatic substitution reaction?
◦ 1) Formation of an electrophile; 2) Reaction of the electrophile with an aromatic ring to form the sigma complex; 3) Deprotonation of the sigma complex to restore aromaticity
◦ 1) Deprotonation of the aromatic ring to increase its reactivity; 2) Addition of the electrophile to form the sigma product; 3) Loss of the leaving group to form the product
◦ 1) Deprotonation of the aromatic ring to form a sigma complex; 2) Reaction of the sigma complex with the electrophile
◦ 1) Polarization of a dihalide, yielding a nucleophile; 2) Reaction of the nucleophile with the aromatic ring to form an electrophile; 3) Loss of the leaving group to restore aromaticity
◦ 1) Reaction of an electrophile with an aromatic ring to form a sigma complex; 2) Deprotonation of the aromatic ring to form the aromatic product
The patient's signature on the informed consent form indicates that the patient understands the
Steps of the Scientific Method
Basic Steps of Hemostasis
What is the value of the equilibrium constant, K, at 25°C for the reaction?
Major Types of Introns