Author Question: Which of the following patients is most likely to benefit from transplantation of thymic tissue or ... (Read 32 times)

ashley · **on:** Jun 25, 2018

Which of the following patients is most likely to benefit from transplantation of thymic tissue or major histocompatibility complex (MHC)-compatible bone marrow?

A)
A 12-year-old girl with a history of epilepsy and low IgG levels secondary to phenytoin use
B)
A 7-year-old boy whose blood work indicates decreased IgA and IgG with increased IgM
C)
A 6-year-old boy whose pre-B cells are incapable of translation to normal B cells
D)
A 9-year-old girl who has a diagnosis of IgA deficiency

Question 2

A 40-year-old male who has been HIV positive for 6 years is experiencing a new increase in his viral load along with a corresponding decrease in his CD4+ count. Which of the following aspects of his immune system is likely to remain most intact?

A)
Presentation of major histocompatibility molecules on body cells
B)
Orchestration of natural killer cells as part of cell-mediated immunity
C)
Activation of B lymphocytes
D)
Phagocytic function of monocytes and macrophages

wtf444 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

Ans:
B

Feedback:

Decreased IgA, IgE, and IgG with increased IgM levels are characteristic of X-linked immunodeficiency with hyper-IgM, a primary cell-mediated immunodeficiency that would respond to thymic tissue transplantation and MHC-compatible bone marrow. Low IgG levels secondary to phenytoin use, X-linked hypogammaglobulinem ia, and selective IgA deficiency are unlikely to be treated with the T-cell-focused treatments like thymic tissue transplantation and MHC-compatible bone marrow.

Answer to Question 2

Ans:
A

Feedback:

The expression of MHC on various cells of the body is not noted to be directly influenced by HIV. However, infected CD4+ cells are compromised in their ability to guide the action of NK cells, to direct phagocytic function of macrophages, and to present antigens that activate B cells.