This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Why does prothrombin G20210A increase the risk of thrombosis? a. Makes prothrombin activation ... (Read 63 times)

FButt

  • Hero Member
  • *****
  • Posts: 519
on: Jun 25, 2018
Why does prothrombin G20210A increase the risk of thrombosis?
 
  a. Makes prothrombin activation easier
  b. Elevates prothrombin levels
  c. Decreases binding of thrombin by antithrombin
  d. Decreases binding of plasminogen to prothrombin

Question 2

When the chromogenic assay for antithrombin is performed, which of the following is true?
 
  a. The colored end-product intensity is inversely proportional to the antithrombin concentration.
  b. The chromogenic substrate is bound by antithrombin.
  c. Warfarin is added to the patient sample before testing to improve sensitivity.
  d. Activated protein C competes for the chromogenic substrate, so it must first be selectively removed.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

k.lashomb

  • Sr. Member
  • ****
  • Posts: 346
Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: B
The prothrombin G20210A mutation results in elevated levels of prothrombin; this increases the risk of thrombosis, although the reason why is not clear.

Answer to Question 2

ANS: A
Antithrombin concentration is inversely proportional to the intensity of end-product color. Heparin is added to the patient plasma before testing to improve sensitivity to antithrombin. A protease, often Xa, is added in excess to an aliquot of the patient sample. Some of this Xa will be bound by the heparin-antithrombin complex and thus inhibited. After this, a chromogenic substrate is added that is specific for Xa. When the residual Xa hydrolyzes this substrate, color will be released. The more antithrombin present in the patient sample, the more Xa will be bound and the less chromogen will be released.


FButt

  • Member
  • Posts: 519
Reply 2 on: Jun 25, 2018
Gracias!

amit

  • Member
  • Posts: 364
Reply 3 on: Yesterday
Great answer, keep it coming :)

« previous next »
 

Did you know?

Asthma attacks and symptoms usually get started by specific triggers (such as viruses, allergies, gases, and air particles). You should talk to your doctor about these triggers and find ways to avoid or get rid of them.

Did you know?

Children with strabismus (crossed eyes) can be treated. They are not able to outgrow this condition on their own, but with help, it can be more easily corrected at a younger age. It is important for infants to have eye examinations as early as possible in their development and then another at age 2 years.

Did you know?

Egg cells are about the size of a grain of sand. They are formed inside of a female's ovaries before she is even born.

Did you know?

Patients should never assume they are being given the appropriate drugs. They should make sure they know which drugs are being prescribed, and always double-check that the drugs received match the prescription.

Did you know?

The toxic levels for lithium carbonate are close to the therapeutic levels. Signs of toxicity include fine hand tremor, polyuria, mild thirst, nausea, general discomfort, diarrhea, vomiting, drowsiness, muscular weakness, lack of coordination, ataxia, giddiness, tinnitus, and blurred vision.

Physical Fitness and Cancer Risk Physical Fitness and Cancer Risk
The Head Start program was designed to increase the school readiness of low-income children. The Head Start program was designed to increase the school readiness of low-income children.
The Increase in Divorce The Increase in Divorce
Metabolic activation of phosphocholine Metabolic activation of phosphocholine
Pathway for vitamin D activation Pathway for vitamin D activation
Activation and Clonal Selection of a Helper T Cell Activation and Clonal Selection of a Helper T Cell
Video: Bone Growth and Remodeling

For a complete list of videos, visit our video library