This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Why does prothrombin G20210A increase the risk of thrombosis? a. Makes prothrombin activation ... (Read 36 times)

FButt

  • Hero Member
  • *****
  • Posts: 519
on: Jun 25, 2018
Why does prothrombin G20210A increase the risk of thrombosis?
 
  a. Makes prothrombin activation easier
  b. Elevates prothrombin levels
  c. Decreases binding of thrombin by antithrombin
  d. Decreases binding of plasminogen to prothrombin

Question 2

When the chromogenic assay for antithrombin is performed, which of the following is true?
 
  a. The colored end-product intensity is inversely proportional to the antithrombin concentration.
  b. The chromogenic substrate is bound by antithrombin.
  c. Warfarin is added to the patient sample before testing to improve sensitivity.
  d. Activated protein C competes for the chromogenic substrate, so it must first be selectively removed.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

k.lashomb

  • Sr. Member
  • ****
  • Posts: 346
Reply #1 on: Jun 25, 2018
Answer to Question 1

ANS: B
The prothrombin G20210A mutation results in elevated levels of prothrombin; this increases the risk of thrombosis, although the reason why is not clear.

Answer to Question 2

ANS: A
Antithrombin concentration is inversely proportional to the intensity of end-product color. Heparin is added to the patient plasma before testing to improve sensitivity to antithrombin. A protease, often Xa, is added in excess to an aliquot of the patient sample. Some of this Xa will be bound by the heparin-antithrombin complex and thus inhibited. After this, a chromogenic substrate is added that is specific for Xa. When the residual Xa hydrolyzes this substrate, color will be released. The more antithrombin present in the patient sample, the more Xa will be bound and the less chromogen will be released.


FButt

  • Member
  • Posts: 519
Reply 2 on: Jun 25, 2018
Wow, this really help

cam1229

  • Member
  • Posts: 329
Reply 3 on: Yesterday
Thanks for the timely response, appreciate it

« previous next »
 

Did you know?

According to the Migraine Research Foundation, migraines are the third most prevalent illness in the world. Women are most affected (18%), followed by children of both sexes (10%), and men (6%).

Did you know?

Amphetamine poisoning can cause intravascular coagulation, circulatory collapse, rhabdomyolysis, ischemic colitis, acute psychosis, hyperthermia, respiratory distress syndrome, and pericarditis.

Did you know?

In 1885, the Lloyd Manufacturing Company of Albany, New York, promoted and sold "Cocaine Toothache Drops" at 15 cents per bottle! In 1914, the Harrison Narcotic Act brought the sale and distribution of this drug under federal control.

Did you know?

The first successful kidney transplant was performed in 1954 and occurred in Boston. A kidney from an identical twin was transplanted into his dying brother's body and was not rejected because it did not appear foreign to his body.

Did you know?

Serum cholesterol testing in adults is recommended every 1 to 5 years. People with diabetes and a family history of high cholesterol should be tested even more frequently.

Risk for falls cont'd Risk for falls cont'd
Increased risk of trisomy with maternal age. Increased risk of trisomy with maternal age.
To increase pressure using body weight, lean on your client. To increase pressure using body weight, lean on your client.
Responses Produced by Activation of Specific Opioid Receptors Responses Produced by Activation of Specific Opioid Receptors
Insig-mediated regulation of SREBP activation Insig-mediated regulation of SREBP activation
How high a hill would a 75-kg hiker have to climb to increase her gravitational potential ... How high a hill would a 75-kg hiker have to climb to increase her gravitational potential ...
Video: Exercise and cardiac output

For a complete list of videos, visit our video library