Why are patients with plasma cell myeloma susceptible to ...

[tth]

Why are patients with plasma cell myeloma susceptible to infection?
 
  a. Decreased lymphocytes
  b. Neutropenia
  c. Suppressed normal immunoglobulin levels
  d. Both b and c

Question 2

Why is Burkitt lymphoma such an aggressive malignancy?
 
  a. Cells readily metastasize to bone marrow.
  b. Cells have a high proliferative rate.
  c. Cells fail to mature to functional immunophenotype.
  d. Cells destroy red cells.

[macagnavarro]

Answer to Question 1

ANS: D
As plasma cells multiply in the bone marrow, normal hematopoiesis, including granulopoiesis, is suppressed. This leads to neutropenia. In addition, normal immunoglobulin (antibodies) is suppressed. Together these contribute to the increased susceptibility to infection seen in these patients.

Answer to Question 2

ANS: B
Burkitt lymphoma cells have a high proliferative rate, with a very short doubling time; almost all the malignant cells are in active phases of the cell cycle at any one time.

[tth]

Thank you

[macagnavarro]

No problemo