Which of the following conditions is associated with a deficiency ...

[kfurse]

Which of the following conditions is associated with a deficiency of von Willebrand factor (VWF)-cleaving protease?
 
  a. Hemolytic uremic syndrome
  b. Thrombotic thrombocytopenic purpura
  c. March hemoglobinuria
  d. DIC

Question 2

An Rh-negative woman is pregnant with her third child. She received little or no prenatal care during the first two pregnancies. Her anti-D titer is 1:512 at 30 weeks of gestation. What is the likely outcome for the baby?
 
  a. ABO hemolytic disease of the newborn
  b. Rh hemolytic disease of the newborn
  c. No or mild hemolysis but spherocytes on the blood film
  d. Most likely not survive

[lorealeza77]

Answer to Question 1

ANS: B
A severe deficiency of VWF-cleaving protease has been described in patients with thrombotic thrombocytopenic purpura.

Answer to Question 2

ANS: B
This baby will most likely have Rh hemolytic disease of the newborn. The mother's antibody titer does not predict the severity of hemolytic disease of the newborn.

[kfurse]

Thanks for the timely response, appreciate it

[amandanbreshears]

TYSM