A bone marrow aspirate shows copious blue granules with the ...

[BRWH]

A bone marrow aspirate shows copious blue granules with the Prussian blue stain. Select the correct interpretation:
 
  a. Iron overload
  b. Iron deficiency
  c. Tumor cells present
  d. Megakaryocytes increased

Question 2

Which of the following cell types tend to be found in molded clusters in the bone marrow?
 
  a. Megakaryocytes
  b. Malignant cells
  c. Immature granulocytes
  d. Monocytes

[atrochim]

Answer to Question 1

ANS: A
The Prussian blue stain is an iron-specific stain (nonheme iron). When iron is in the storage form of hemosiderin, it stains blue. If copious granules are visible, then it suggests iron overload. The granules must be found in macrophage cytoplasm to rule out possible contamination of the slide or stain with iron.

Answer to Question 2

ANS: B
Malignant cells are often found in clusters or clumps in the bone marrow. Because they are so large, they are most easily searched for under 10 while scanning, and they are often found at or near the edge of the coverslip (or glass slide).

[BRWH]

TYSM

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