What substances in segmented neutrophils are important for ...

[viki]

What substances in segmented neutrophils are important for intracellular killing of bacteria?
 
  a. Alkaline phosphatase and halides
  b. Myeloperoxidase and superoxide
  c. Collagenase and hydrogen peroxide
  d. Acid phosphatase and anions

Question 2

CD34 is an antigen found on which one of the following cells?
 
  a. Myeloblast
  b. Segmented neutrophil
  c. Eosinophil
  d. Lymphocyte

[cici]

Answer to Question 1

ANS: B
Bacteria killing is a complex mechanism, requiring activation of the neutrophil, ingestion of the bacterium, and incorporation into a phagosome. Cytoplasmic granules fuse with the lysosome and dump their contents. Myeloperoxidase, halides, hydrogen peroxide, and the formation of superoxide and oxygen radicals are all instrumental for killing. Also critical for killing is activation of proteinases such as cathepsin G.

Answer to Question 2

ANS: A
CD34 is found on the myeloblast and also the promyelocyte, but it is downregulated as the cell continues to mature and is not found on mature cells of any lineage.