This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Beginning with the trauma, what is the sequence of events that leads to the formation of a clot ... (Read 87 times)

nenivikky

  • Hero Member
  • *****
  • Posts: 516
on: Jun 25, 2018
Beginning with the trauma, what is the sequence of events that leads to the formation of a clot (thrombus)? .
 
  What will be an ideal response?

Question 2

Correlate blood vessel histology to vessel type and function in hemostasis.
 
  What will be an ideal response?


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

jlaineee

  • Sr. Member
  • ****
  • Posts: 380
Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer:
1. Trauma occurs.
2. Subendothelial collagen is exposed.
3. Vasoconstriction is initiated to minimize blood loss.
4. Platelets become activated as a result of the subendothelial collagen  (a) flat, discoid shape  spiked appearance, (b) actin and myosin go from a random arrangement to a parallel arrangement; (c) tubulin forms a circumferential band around the organelle zone to assist in expelling granular contents to the surface of the platelets.
5. Activated platelets adhere to subendothelial collagen with the help of VWF and GP Ib/IX.
6. Once adhesion takes place, more platelets are recruited to the site, and aggregation is initiated. Substances needed for platelet aggregation is fibrinogen and GP IIb/IIIa.
7. Platelets secrete their granular contents and initiate secondary hemostasis.
8. Secondary hemostasis is activated by contact activation and subsequent progression into the coagulation cascade via the intrinsic and extrinsic pathways.
9. The end result is the formation of an insoluble fibrin polymer that stabilizes the platelet plug.
10. Fibroblasts grow and regenerate with the help of PDGF and other tissue repair chemokines.
11. Once repair is completed, the fibrinolysis pathway is activated.
12. Fibrin and tPA induce activation of plasmin from plasminogen.
13. Plasmin chemically digests the fibrin polymer into measurable fragments that can be detected in vitro.
14. Normal homeostasis is restored.

Answer to Question 2

Answer: Tunica adventitia: thick outer layer of the blood vessels responsible for maintaining blood pressure; is thicker in veins than in arteries
Tunica media: middle layer responsible for vasoconstriction and vasodilation; is thicker in arteries than in veins
Tunica intima: has direct interaction with peripheral blood constituents; all three types of vessels (arteries, veins, and capillaries) in close tunica intima layers


nenivikky

  • Member
  • Posts: 516
Reply 2 on: Jun 25, 2018
:D TYSM

emsimon14

  • Member
  • Posts: 344
Reply 3 on: Yesterday
Excellent

« previous next »
 

Did you know?

Immunoglobulin injections may give short-term protection against, or reduce severity of certain diseases. They help people who have an inherited problem making their own antibodies, or those who are having certain types of cancer treatments.

Did you know?

Walt Disney helped combat malaria by making an animated film in 1943 called The Winged Scourge. This short film starred the seven dwarfs and taught children that mosquitos transmit malaria, which is a very bad disease. It advocated the killing of mosquitos to stop the disease.

Did you know?

Acute bronchitis is an inflammation of the breathing tubes (bronchi), which causes increased mucus production and other changes. It is usually caused by bacteria or viruses, can be serious in people who have pulmonary or cardiac diseases, and can lead to pneumonia.

Did you know?

The first-known contraceptive was crocodile dung, used in Egypt in 2000 BC. Condoms were also reportedly used, made of animal bladders or intestines.

Did you know?

People who have myopia, or nearsightedness, are not able to see objects at a distance but only up close. It occurs when the cornea is either curved too steeply, the eye is too long, or both. This condition is progressive and worsens with time. More than 100 million people in the United States are nearsighted, but only 20% of those are born with the condition. Diet, eye exercise, drug therapy, and corrective lenses can all help manage nearsightedness.

An electrocardiogram (EKG) wave, a record of the electrical signal as it moves through the conductio An electrocardiogram (EKG) wave, a record of the electrical signal as it moves through the conductio
Major Events in the History of Psychology (5 of 6) Major Events in the History of Psychology (5 of 6)
Guidelines and Precautions Prior to Beginning a Strength-Training Program Guidelines and Precautions Prior to Beginning a Strength-Training Program
The Process of Sperm Formation The Process of Sperm Formation
Formation of a peptide bond between two amino acids Formation of a peptide bond between two amino acids
Timeline of Major Events in Plants Timeline of Major Events in Plants
Video: Spermatogenesis Animation

For a complete list of videos, visit our video library