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Author Question: Explain the molecular and cytogenetic profile of a patient with Burkitt lymphoma. What will be an ... (Read 75 times)

silviawilliams41

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on: Jun 25, 2018
Explain the molecular and cytogenetic profile of a patient with Burkitt lymphoma.
 
  What will be an ideal response?

Question 2

Morphological differences between ALL and Burkitt-type ALL include which of the following?
 
  a. Cell size, nuclear shape, and nuclear chromatin
  b. Cell size, cytoplasmic basophilia, and cellular heterogeneity
  c. Nucleoli, cytoplasmic volume, and vacuolation
  d. Cell size, cytoplasmic basophilia and vacuolation, and prominent nucleoli


kilada

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer:
Cytogenetic: Translocation of the MYC gene (8q24) to the heavy chain region on chromosome 14 (t(8,14)) or to light chain loci on chromosome 2p12 (t(2,8))
Molecular profile: clonal rearrangement of immunoglobulin heavy and light chain genes

Answer to Question 2

Correct Answer: D


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