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The use of salicylates dates back 2,500 years to Hippocrates’s recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
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Your heart beats over 36 million times a year.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Oliver Wendell Holmes is credited with introducing the words "anesthesia" and "anesthetic" into the English language in 1846.
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For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.