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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
About one in five American adults and teenagers have had a genital herpes infection—and most of them don't know it. People with genital herpes have at least twice the risk of becoming infected with HIV if exposed to it than those people who do not have genital herpes.
On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.
Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.