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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
Each year in the United States, there are approximately six million pregnancies. This means that at any one time, about 4% of women in the United States are pregnant.
The types of cancer that alpha interferons are used to treat include hairy cell leukemia, melanoma, follicular non-Hodgkin's lymphoma, and AIDS-related Kaposi's sarcoma.
About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
![Changes in boreal forest composition along a chronosequence in Quebec. Dates refer to the year of th](https://biology-forums.com/gallery/47/medium_33_17_02_12_6_53_46_20141497.jpeg)
![The nitrogen cycle. Numbers represent fluxes as 1012 g N per year (data from Schlesinger 1991, after](https://biology-forums.com/gallery/47/medium_33_17_02_12_7_02_17_2038129.jpeg)