Factors that affect the pharmacokinetics of lipophilic ...

[wrbasek0]

Factors that affect the pharmacokinetics of lipophilic medications in older adults include:
 
  a. greater adipose tissue ratio to body mass.
  b. decreased total body water.
  c. increased glomerular filtration rate.
  d. increased creatinine clearance.

Question 2

When a client asks, What could be causing my triglycerides to be so low; I'm really careful about my diet? the nurse responds by asking the client: (Select all that apply.)
 
  a. Is your type 2 diabetes well managed?
  b. Have you ever been diagnosed with renal failure?
  c. Do you have a history of pancreatitis?
  d. Are you on medication for hyperthyroid-ism?
  e. Could you tell me how you are careful about your diet?

[joewallace]

Answer to Question 1

ANS: A
Older adults have a higher ratio of adipose (fat) tissue where lipophilic (fat-soluble) medications can be stored thus resulting in a potential for an accumulation of the medication and potentially fatal overdoses. Older adults have a decrease in lean body mass and an increase in fat. An in-creased body mass would not affect lipophilic medication absorption. Older adults have a de-creased glomerular filtration rate, which begins to decline as early as age 25. Older adults have a decrease in overall kidney function.

Answer to Question 2

ANS: D, E
Abnormally low triglyceride levels are suggestive of malnutrition or hyperthyroidism. Reasons for elevated levels include chronic renal failure and poorly controlled diabetes. Severely elevated triglyceride levels (greater than 2000 mg/dL) are a strong risk factor for pancreatitis.

[wrbasek0]

TYSM

[mohan]

Excellent