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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
Never take aspirin without food because it is likely to irritate your stomach. Never give aspirin to children under age 12. Overdoses of aspirin have the potential to cause deafness.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
Asthma cases in Americans are about 75% higher today than they were in 1980.