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Once thought to have neurofibromatosis, Joseph Merrick (also known as "the elephant man") is now, in retrospect, thought by clinical experts to have had Proteus syndrome. This endocrine disease causes continued and abnormal growth of the bones, muscles, skin, and so on and can become completely debilitating with severe deformities occurring anywhere on the body.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
Oliver Wendell Holmes is credited with introducing the words "anesthesia" and "anesthetic" into the English language in 1846.
If you could remove all of your skin, it would weigh up to 5 pounds.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.