Answer to Question 1
2
Rationale: CD4+ counts are used to assess a young child's immune status, risk for disease pro-gression, and need for P. jiroveci pneumonia prophylaxis after 1 year of age. These counts are measured at 1 and 3 months, every 3 months until the age of 2 years, and at least every 6 months thereafter. More frequent monitoring of CD4+ counts is indicated when P. jiroveci pneumonia prophylaxis and antiretroviral therapy are recommended. The CD4+ count is not diagnostic of HIV infection.
Answer to Question 2
2
Rationale: Cisplatin (Platinol-AQ) is an alkylating-like medication, and vincristine (Oncovin) is a vinca alkaloid. Alkylating medications are cell cycle phasenonspecific. Vinca alkaloids are cell cycle phasespecific and act on the M phase. Single-agent medication therapy seldom is used. Combinations of medications are used to increase the destruction of tumor cells.