A nurse is preparing to administer gemfibrozil to a client. The ...

[BrownTown3]

A nurse is preparing to administer gemfibrozil to a client. The nurse understands that this drug lowers cholesterol via which of the following mechanisms? Select all that apply.
 
  A) Increases excretion of cholesterol
  B) Reduces very-low-density lipoproteins (VLDLs)
  C) Increases breakdown of VLDLs
  D) Reduces production of triglycerides
  E) Inhibits cholesterol formation

Question 2

A client is currently taking propranolol (Inderal) for hypertension, glipizide (Glucotrol) for diabetes, and acetaminophen (Tylenol) for osteoarthritis. If cholestyramine was given to this client, which of the following would likely result?
 
  Select all that apply.
 
  A) The client would experience hypoglycemia from increased absorption of glipizide.
  B) The client would experience decreased analgesia from decreased absorption of acetaminophen.
  C) The client would experience an increase in blood pressure due to decreased absorption of propranolol.
  D) The client would experience hypotension from increased absorption of propranolol.
  E) The client would experience hyperglycemia from decreased absorption of glipizide.

[bulacsom]

Answer to Question 1

Ans: A, D
Feedback:
Gemfibrozil increases the excretions of cholesterol and reduces the production of triglycerides. The drug does not reduce VLDLs, increase VLDL breakdown, or inhibit cholesterol formation.

Answer to Question 2

Ans: C, E
Feedback:
The use of bile acid resins, like cholestyramine, decreases the absorption of some medications including glipizide and propranolol. This decreased absorption could result in hyperglycemia and an increase in blood pressure for this particular client.

[BrownTown3]

Thanks

[bulacsom]

Welcome