Answer to Question 1
ANS: D
Nausea and vomiting, which occur with migraines, can increase with ergotamine use, because the drug can stimulate the chemoreceptor trigger zone. Patients should be treated with metoclopramide or a phenothiazine antiemetic. It is not necessary to change antimigraine medications at this time. Nausea and vomiting do not indicate ergotamine toxicity. These symptoms will not diminish over time.
Answer to Question 2
ANS: B, D, E
With continuous use, tolerance develops to most side effects of opioids, except to constipation and physical dependence.