Author Question: The nurse is describing the mechanism of action of antimetabolites to a client with cancer. Which ... (Read 23 times)

SGallaher96 · **on:** Jul 23, 2018

The nurse is describing the mechanism of action of antimetabolites to a client with cancer. Which statement best describes how the antimetabolites kill cancer cells?

1. They use the body's immune system to kill tumor cells.
2. They disrupt metabolic pathways, slowing growth of cancer cells.
3. They contain bacterial substances that can kill cancer cells.
4. They change the shape of the DNA and prevent division of cancer cells.

Question 2

The nurse is reviewing medications that are similar to methotrexate. Which medications are closely related to methotrexate?

Standard Text: Select all that apply.
1. Pemetrexed
2. Pralatrexate
3. Idarubicin
4. Plicamycin
5. Doxorubicin

Liamb2179 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 2
Rationale 1: This describes biologic response modifiers.
Rationale 2: This describes antimetabolites.
Rationale 3: This describes antibiotic antineoplastics.
Rationale 4: This describes alkylating agents.
Global Rationale: Antimetabolites disrupt the critical cellular pathways of cancer cells which slows growth or kills the cell. Biologic response modifiers use the body's immune system to kill tumor cells. Antibiotic antineoplastics contain bacterial substances that can kill cancer cells. Alkylating agents change the shape of the DNA and prevent division of cancer cells.

Answer to Question 2

Correct Answer: 1,2
Rationale 1: Pemetrexed is a medication that is similar in action to methotrexate.
Rationale 2: Pralatrexate is a medication that is similar in action to methotrexate.
Rationale 3: Idarubicin is an antibiotic antineoplastic. It is not similar to methotrexate.
Rationale 4: Plicamycin is an antibiotic antineoplastic. It is not similar to methotrexate.
Rationale 5: Doxorubicin is an antibiotic antineoplastic. It is not similar to methotrexate.
Global Rationale: Pemetrexed and pralatrexate are both similar in action to methotrexate. Idarubicin, plicamycin, and doxorubicin are antibiotic antineoplastics.