This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Salicylates primarily inhibit the synthesis of which substance? 1. Pyrogens 2. Superoxide ... (Read 30 times)

washai

  • Hero Member
  • *****
  • Posts: 523
on: Jul 23, 2018
Salicylates primarily inhibit the synthesis of which substance?
 
  1. Pyrogens
  2. Superoxide radicals
  3. Histamines
  4. Prostaglandins

Question 2

Aspirin has which adverse effect on the gastrointestinal mucosa?
 
  1. Aspirin causes direct cellular injury as it is absorbed across the stomach mucosa.
  2. Because all aspirin products have an enteric coating, there is no topical damage to the stomach.
  3. After aspirin is systemically absorbed, it inhibits COX-2.
  4. Aspirin enhances the effect of prostaglandins' protective function to the GI mucosa.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

gstein359

  • Sr. Member
  • ****
  • Posts: 293
Reply #1 on: Jul 23, 2018
Answer to Question 1

Correct Answer: 4
Rationale 1: Pyrogens are substances that increase body temperature. Salicylates do not act directly on the pyrogens.
Rationale 2: Superoxide radicals are blocked by ibuprofen.
Rationale 3: Histamines are an important chemical substance released during the inflammatory process and are not blocked by salicylates.
Rationale 4: Aspirin blocks the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase (COX).
Global Rationale: All NSAIDs act by inhibiting the synthesis of prostaglandins which are local hormones found in virtually every tissue. Prostaglandins have many diverse functions depending on their location. Pyrogens are substances that increase body temperature. Salicylates do not act directly on the pyrogens. Superoxide radicals are blocked by ibuprofen. Histamines are an important chemical substance released during the inflammatory process and are not blocked by salicylates.

Answer to Question 2

Correct Answer: 1
Rationale 1: Aspirin causes topical damage to the stomach as it crosses the mucosa. This direct cellular injury can result in GI bleeding.
Rationale 2: Not all aspirin products are enteric-coated.
Rationale 3: Aspirin inhibits COX-1 once it is systemically absorbed; it depletes the GI mucosa of prostaglandin.
Rationale 4: Aspirin depletes the GI mucosa of prostaglandins.
Global Rationale: As aspirin is absorbed across the stomach mucosa, it causes direct cellular injury. This topical damage to the stomach may be lessened by the use of enteric-coated formulations. After aspirin is absorbed systemically, it inhibits COX-1 and depletes the GI mucosa of prostaglandins which normally provide a protective function by directing the secretion of mucus and bicarbonate and promoting cellular repair of mucosal damage. Not all aspirin products are enteric-coated.


washai

  • Hero Member
  • *****
  • Posts: 523
Reply #2 on: Jul 23, 2018
Both answers were spot on, thank you once again


gstein359

  • Sr. Member
  • ****
  • Posts: 293
Reply #3 on: Jul 23, 2018
Great! Please up vote :D


« previous next »
 

Did you know?

The use of salicylates dates back 2,500 years to Hippocrates’s recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.

Did you know?

A recent study has found that following a diet rich in berries may slow down the aging process of the brain. This diet apparently helps to keep dopamine levels much higher than are seen in normal individuals who do not eat berries as a regular part of their diet as they enter their later years.

Did you know?

Congestive heart failure is a serious disorder that carries a reduced life expectancy. Heart failure is usually a chronic illness, and it may worsen with infection or other physical stressors.

Did you know?

Carbamazepine can interfere with the results of home pregnancy tests. If you are taking carbamazepine, do not try to test for pregnancy at home.

Did you know?

Patients who cannot swallow may receive nutrition via a parenteral route—usually, a catheter is inserted through the chest into a large vein going into the heart.

Furchgott's discovery that endothelial cells produce a vasodilating substance. Furchgott's discovery that endothelial cells produce a vasodilating substance.
Apply the substance to the client’s upper chest. Apply the substance to the client’s upper chest.
A general scheme for adding one amino acid in solid-phase peptide synthesis A general scheme for adding one amino acid in solid-phase peptide synthesis
The cross-linking reaction in peptidoglycan synthesis (left) and inhibition of the transpeptidase The cross-linking reaction in peptidoglycan synthesis (left) and inhibition of the transpeptidase
Stage 2: Synthesis of Squalene from Mevalonate Stage 2: Synthesis of Squalene from Mevalonate
De novo synthesis of pyrimidine nucleotides (Detailed) De novo synthesis of pyrimidine nucleotides (Detailed)
Video: Attention Deficit Disorder (ADD)

For a complete list of videos, visit our video library