Author Question: The nurse is researching a drug that has a median effective dose (ED50) of 5 mg and a median lethal ... (Read 100 times)

mia · **on:** Jul 23, 2018

The nurse is researching a drug that has a median effective dose (ED50) of 5 mg and a median lethal dose (LD50) of 20 mg. Which therapeutic index (TI) calculated by the nurse is correct?

1. 5
2. 4
3. 1
4. 10

Question 2

The nurse checks the margin of safety (MOS) for a drug that will be administered to a client, knowing that the MOS is the amount of drug that is lethal to ____ of animals divided by the amount that produces a therapeutic effect in ____ of animals.

Fill in the blank with the appropriate word.

Bsand8 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 2
Rationale 1: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 does not equal 5.
Rationale 2: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 equals 4.
Rationale 3: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 does not equal 1.
Rationale 4: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 does not equal 10.
Global Rationale: The TI is calculated by dividing the median LD by the median ED. Twenty divided by 5 equals 4.

Answer to Question 2

Correct Answers: 1, 99
Rationale: The MOS is calculated as the amount of drug that is lethal to 1 of animals (LD1) divided by the amount of drug that produces a therapeutic effect in 99 of the animals (ED99).
Global Rationale: The MOS is calculated as the amount of drug that is lethal to 1 of animals (LD1) divided by the amount of drug that produces a therapeutic effect in 99 of the animals (ED99).