Author Question: Which of the following laboratory tests relates most directly with the impaired drug elimination ... (Read 81 times)

lak · **on:** Jul 23, 2018

Which of the following laboratory tests relates most directly with the impaired drug elimination that is expected in neonates?

A) C-reactive protein level
B) Creatine kinase
C) Serum albumin level
D) Glomerular filtration rate

Question 2

A patient has begun taking cholestyramine. Which of the following are noted as the most common adverse effects?

A) Nausea, flatulence, and constipation
B) Increased appetite and blood pressure
C) Fatigue and mental disorientation
D) Hiccups, nasal congestion, and dizziness

epscape · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

D
Feedback:
Excretion of most drugs occurs via the kidneys, and elimination in the urine follows. Young children have immature kidneys, a reduced glomerular filtration rate, and slower renal clearance. Neonates are especially prone to increased levels of drugs that are eliminated primarily by the kidneys. CK, albumin, and C-reactive protein levels do not directly relate to this physiological characteristic.

Answer to Question 2

A
Feedback:
Cholestyramine is not absorbed systemically, so the main adverse effects are gastrointestinal (GI) ones (abdominal fullness, flatulence, diarrhea, and constipation). Constipation is especially common, and a bowel program may be necessary to control this problem.