Answer to Question 1
The extensive tissue damage that develops in long-term gastritis may disrupt gastric secretory functions and increase the risk of cancer. When autoimmune disease is the cause of atrophic gastritis, it frequently leads to destruction of the stomach cells that produce hydrochloric acid and intrinsic factor. If hydrochloric acid secretions become abnormally low or absent, absorption of nonheme iron and vitamin B12 can be impaired, increasing the risk of deficiency. Lack of intrinsic factor can result in vitamin B12 malabsorption and the vitamin B12-deficiency condition known as pernicious anemia; possible consequences include macrocytic anemia and neurological damage. Dietary recommendations depend on an individual's symptoms. In asymptomatic cases, no dietary adjustments are needed. If pain or discomfort is present, the patient should avoid irritating foods and beverages; these often include alcohol, coffee (including decaffeinated), cola beverages, spicy foods, and fried or fatty foods. If food consumption increases pain or causes nausea and vomiting, food intake should be avoided for 24 to 48 hours to rest the stomach. If hypochlorhydria or achlorhydria is present, supplementation of iron and vitamin B12 may be warranted.
Answer to Question 2
B