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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.

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The toxic levels for lithium carbonate are close to the therapeutic levels. Signs of toxicity include fine hand tremor, polyuria, mild thirst, nausea, general discomfort, diarrhea, vomiting, drowsiness, muscular weakness, lack of coordination, ataxia, giddiness, tinnitus, and blurred vision.

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The first successful kidney transplant was performed in 1954 and occurred in Boston. A kidney from an identical twin was transplanted into his dying brother's body and was not rejected because it did not appear foreign to his body.

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In 1864, the first barbiturate (barbituric acid) was synthesized.

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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.

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