Author Question: Assume that 30 mg of drug A puts 10 of people to sleep and that 100 mg of drug A puts 80 of people ... (Read 39 times)

roselinechinyere27m · **on:** Jun 22, 2018

Assume that 30 mg of drug A puts 10 of people to sleep and that 100 mg of drug A puts 80 of people to sleep. Assume that drug B has no effect on sleep at any dose (except at lethal doses).

If we give 100 mg of drug B along with 30 mg of drug A, we observe that the combination puts 50 of people to sleep. What phenomenon are we observing? Explain your answer.
What will be an ideal response?

Question 2

Describe or define the following terms: active placebo:

What will be an ideal response?

fur · **Reply #1 on:** Jun 22, 2018

Answer to Question 1

Since drug B has no effect on sleep by itself and the 30 mg dose of drug A when combined with the dose of drug B produces effects greater than the effects induced by 30 mg of drug A alone, this would indicate that we are observing potentiation, a form of synergism.

Answer to Question 2

A compound with some of the discriminable qualities of a test drug whose clinical properties are being evaluated, but without the specific clinical properties of the test drug. The efficacy of the active placebo is then compared with that of the test drug.