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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
Although puberty usually occurs in the early teenage years, the world's youngest parents were two Chinese children who had their first baby when they were 8 and 9 years of age.
By definition, when a medication is administered intravenously, its bioavailability is 100%.