Answer to Question 1
They alter the normal metabolism of a dietary amino acid, tyramine, such that if an individual consumes foods with a high tyramine content while taking MAO inhibitors, a hypertensive (high blood pressure) crisis can result. A severe headache, palpitations, flushing of the skin, nausea, and vomiting are some symptoms of this reaction, which has in some cases ended in death from a stroke. Patients taking MAO inhibitors must also avoid sympathomimetic drugs, such as amphetamines, methylphenidate, and ephedrine.
Answer to Question 2
B