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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
In 1864, the first barbiturate (barbituric acid) was synthesized.
Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
The average office desk has 400 times more bacteria on it than a toilet.
Warfarin was developed as a consequence of the study of a strange bleeding disorder that suddenly occurred in cattle on the northern prairies of the United States in the early 1900s.