Water loss through the epidermis could cause a serious threat to health and well-being. Which of the following protects us against excessive water loss through the skin?
◦ The dermis is the thickest portion of the skin and water cannot pass through it.
◦ The size and shape of the cells that make up the stratum spinosum, as well as the thick bundles of intermediate filaments.
◦ Fat associated with skin prevents water loss.
◦ Glycolipids that are secreted by keratinocytes into extracellular spaces.