Question 1
Ibrahim is suffering from hypothyroidism. What is hypothyroidism? How could his physician determine whether the malfunction is in the hypothalamus and pituitary or at the level of the gland itself?
Question 2
Naura is a 15-year-old girl but has never had a menstrual period, though she has other signs of puberty such as breasts and pubic and axillary hair. During a pelvic exam her physician determines that she has no uterus. Blood tests reveal that she has increased levels of testosterone in her blood, similar to that expected in young adult males. Name two typical sources of testosterone. Given the lack of a uterus, what is the likely source of testosterone in this case? She might have which pathology or mutation? (Hint: Consider general principles of hormone secretion and action.) Why is there no uterus? What genetic test may confirm this suspicion?
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