Hemoglobin S (HbS) is formed in sickle cell disease as a result of which process?
◦ Deficiency in glucose 6-phosphate dehydrogenase (G6PD) that changes hemoglobin A (HbA) to HbS.
◦ Genetic mutation in which two amino acids (histidine and leucine) are missing.
◦ Genetic mutation in which one amino acid (glutamate) is replaced by another (valine).
◦ Autoimmune response in which one amino acid (proline) is detected as an antigen by abnormal immunoglobulin G (IgG).