Question 1
Hydrops fetalis, which is fatal at or before birth, is caused by:
◦ a large deletion in ε globin genes.
◦ a large deletion in α globin genes.
◦ a large deletion in β globin genes.
◦ complete absence of ζ globin genes.
◦ complete absence of α globin genes.
Question 2
Mutations that reduce or prevent synthesis of either α or β globin result in:
◦ immediate lethality.
◦ hydrops fetalis.
◦ thalassemias.
◦ HbH disease.
◦ Hb anti-Lepore.