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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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The longest a person has survived after a heart transplant is 24 years.
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Your heart beats over 36 million times a year.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.