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Once thought to have neurofibromatosis, Joseph Merrick (also known as "the elephant man") is now, in retrospect, thought by clinical experts to have had Proteus syndrome. This endocrine disease causes continued and abnormal growth of the bones, muscles, skin, and so on and can become completely debilitating with severe deformities occurring anywhere on the body.
Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
Approximately 500,000 babies are born each year in the United States to teenage mothers.
Asthma cases in Americans are about 75% higher today than they were in 1980.
This year, an estimated 1.4 million Americans will have a new or recurrent heart attack.