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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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There are more sensory neurons in the tongue than in any other part of the body.
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Certain topical medications such as clotrimazole and betamethasone are not approved for use in children younger than 12 years of age. They must be used very cautiously, as directed by a doctor, to treat any child. Children have a much greater response to topical steroid medications.
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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.