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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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A headache when you wake up in the morning is indicative of sinusitis. Other symptoms of sinusitis can include fever, weakness, tiredness, a cough that may be more severe at night, and a runny nose or nasal congestion.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.