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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Multiple experimental evidences have confirmed that at the molecular level, cancer is caused by lesions in cellular DNA.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Colchicine is a highly poisonous alkaloid originally extracted from a type of saffron plant that is used mainly to treat gout.